SYNTHESIS OF UNSYMMETRICAL THIOUREA DERIVATIVES

Asieh Yahyazadeh, Zahra Ghasemi

Abstract


A  series  of  thiourea  derivatives  have  been  synthesized.  Thiourea  derivatives  show  a  broad  spectrum  of  biological  activities  such  as  antibacterial, antiviral, anticancer, anticonvulsion, analgesic  an HDL-elevating. Ethyl isothiocyanate  and  aromatic  amines  were mixed  and  stirred  at  room  temperature  in  acetone  for  15h  to  give  the  corresponding thioureas  in  high  yields.  Their  structures  were  confirmed  by  IR  and  1H-NMR.  By addition e-donor groups to aromatic amines, thioureas were synthesized in high yields.

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DOI: http://dx.doi.org/10.17628/ecb.2013.2.573-575

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