CONDENSATION REACTION BETWEEN 3-ACETYLCOUMARINE AND ARYL ALDEHYDES IN THE PRESENCE OF L-PROLINE

Malihe Kamalpour, Farahnaz K. Behbahani

Abstract


3-Acetylcoumarine and a series a coumarin-chalcone hybrid compounds have been synthesized in good- to-excellent yields using a simple and efficient method. This method involved the one-pot reaction of salicylaldehyde, an α-ketoester to afford 3-acetylcoumarine and the product has been treated with an aromatic aldehyde using L-proline as a bioorganic catalyst to yield 1-(3̒-coumarinyl)-3-aryl-2-propen-1-one (3-cinnamoylcoumarins).

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DOI: http://dx.doi.org/10.17628/ecb.2019.8.336-338

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