A new key for old lock: Glycerol as an OH-acid catalyzed one-pot three-component andfully green synthesis of 3,4-dihydropyrimidin-2(1H)-one and thiones

S. Golshani Anvar, Farahnaz Kargar Behbahani


Synthesis of 3,4-dihydropyrimidin-2(1H)-one and 3,4-dihydropyrimidin-2(1H)-thione derivatives from aldehydes, ethyl acetoacetate and urea or thiourea using glycerol as an organo OH-acid, green and reusable catalyst is reported. The practical and simple protocol led to excellent yields of the dihydropyrimidin-2(1H)-one and thiones under mild reaction conditions and within short span of reaction times with easy reaction workup by maintaining excellent atom economy.

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DOI: http://dx.doi.org/10.17628/ecb.2019.8.301-306


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