SYNTHESIS OF NOVEL SUBSTITUTED-BENZO[d]THIAZOLE-2,4-DICARBOXAMIDES HAVING KINASE INHIBITION AND ANTI-PROLIFERATIVE ACTIVITY

D. D. Gaikwad, C.D. Pawar, D.N. Pansare, S. L. Chavan, U.D. Pawar, R.H. Shelke, S.L. Chavan, R.P. Pawar, A.M. Zine

Abstract


A series of novel derivatives containing N4-(4-fluorophenyl)-N2-substitured-benzo[d]thiazole-2,4-dicarboxamides were synthesized via an efficient, mild and convenient multistep reaction protocol with excellent yields. The structure of the synthesize compounds were confirmed by IR, 1H NMR, 13C NMR, 19F NMR, mass spectra, elemental analysis and purity was checked by HPLC. All synthesized compounds were screened for anticancer activity against A-549 and Du-145 cancer cell lines by MTT assay. The preliminary bioassay suggests that most of the compounds show anti-proliferation with different degrees. The synthesized compound shows IC50 values in the range of 1.52-17.18 μM in both cell lines. The compounds having electron donating groups had higher anticancer activity compared compounds with electron withdrawing substitutions.

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DOI: http://dx.doi.org/10.17628/ecb.2019.8.78-84

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