ONE POT MULTICOMPONENT SYNTHESIS OF HIGHLY FUNCTIONALIZED PYRIDINES USING MORPHOLINE ORGANOBASE CATALYST

Sushama S. Kauthale, Sunil U. Tekale, Vijay P. Pagore, Kishor G. Huge, Rajendra P. Pawar

Abstract


An atom efficient synthesis of polysubstituted dihydropyridine derivatives was  accomplished by the one-pot four-component condensation of aldehydes, amines, dialkyl acetylene dicarboxylates and active methylene group-containing compounds such as malononitrile or ethyl cyanoacetate using morpholine as a  catalyst at ambient temperature. Broad substrate scope, non-chromatographic purification, good yields of the products makes it be a useful and valuable methodology for employing the 1,4-dipolar intermediates in synthetic organic chemistry. Use of organobase as a single catalyst, room temperature conditions renders the method protocol as a significant addition to the existing methods for the synthesis of multifunctionalized dihydropyridines.

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DOI: http://dx.doi.org/10.17628/ecb.2019.8.71-77

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