SYNTHESIS AND ANTICANCER EVALUATION OF NEW BENZENESULFONAMIDE DERIVATIVES

R N. Shelke, Dattatraya N. Pansare, Chandraknat D. Pawar, Mininath C. Khade, Vrushali N. Jadhav, Satish U. Deshmukh, Ajit K. Dhas, Pravin N. Chavan, Aniket P. Sarkate, Rajendra P. Pawar, Devanand B. Shinde, Shankar R. Thopate

Abstract


A highly efficient protocol was developed for the synthesis of 3-(indoline-1-carbonyl)-N-(substituted)benzenesulfonamide compounds with excellent yields. The in vitro anticancer activity of the new 3-(indoline-1-carbonyl)-N-(substituted)benzenesulfonamide derivatives against A549 (lung cancer cell), HeLa (cervical), MCF-7 (breast cancer cell) and Du-145 (prostate cancer cell) cell lines were studied. Most of the tested compounds showed anticancer activity (IC50 values ranged between 1.98 and 9.12 µM against different cell lines).

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DOI: http://dx.doi.org/10.17628/ecb.2019.8.1-6

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