Efficient Knoevenagel Condensation catalyzed by Nickel Complexes

Manojkumar U. Chopade


During recent years transition metal has found its way to the synthesis of biologically active natural product in organic synthesis. The continue internet to synthesis of biologically active compound we have plan for development of Nickel catalyzed novel methodology, Knoevenagel condensation of aldehyde with ethyl cyano acetate to provide Alpha cyano ethyl cinnamate. The corresponding adducts were obtained in good yields (78-92%) under simple and clean condition.


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DOI: http://dx.doi.org/10.17628/ecb.2018.7.345-347


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