Bmim]OH mediated new synthesis 3-(1H-Indol-3-Yl)Acrylonitrile derivatives

Chekrapani Kesari, Shravankumar Kankala


[Bmim]OH mediated new synthesis of 3-(1H-Indol-3-Yl)Acrylonitrile derivatives 6 have been developed by the reaction of diethylphthalate 1 with ethyl cyanohydrazide 2  to form 3-(1, 4-dioxo-3, 4-dihydrophthalazin-(1H)-yl)-3-oxopropanenitrile 3. Then compound 3 reacted with indole-3-aldehyde 4 by Knoevenagel condensation to form compound (E)-2-(1, 4-dioxo-1, 2, 3, 4-tetrahydrophthalazine-2-carbonyl)-3-(1H-indol-3-yl)acrylonitriles 5. Compound 5 under go alkylation with alkylating agents to form 6 with good yields. Compound 6 could also be synthesized by alkylation of 4 followed by condensation with 3. 

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