Chemical Composition and Biological Activity of Calotropis gigantea Leaf Essential Oil

Minakshi Singh, Menka Surana, Kalim Javed


Essential oil from Calotropis gigantea (L) leaves was extracted by hydro distillation method followed of solvent extraction and characterized by GC-FID and GC-MS techniques. The chemical profiling estimated the presence of 42 components, representing 82.5% of the total oil composition. Phytol (17.94%), phenylacetaldehyde (9.16%), 4-methyl-1-heptanol (4.98%), benzyl alcohol (4.10%), 4-vinyl guaiacol (3.87%), 4-methyl-3-penten-1-ol (3.83%), Gentanol (2.93%), 2-hexyn-1-ol (2.86%) and phenethyl alcohol (2.52%) were found to be the major constituents. Further, biological activities of the extracted oil were studied on the fungal (Candida albicans) and bacterial (Escherichia Coli, Pseudomonas aeruginosa and Staphylococcus aureus) pathogens. 100μl essential oil extracted from leaf shows effective antimicrobial activity against selective bacterial and fungal pathogens. Among bacterial pathogens, leaf oil showed highest antimicrobial activity against Pseudomonas aeruginosa followed by Escherichia Coli and Staphylococcus aureus.

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