ANTIMICROBIAL ACTIVITIES OF COMPOUNDS ISOLATED FROM PYCNANTHUS ANGOLENSIS (WELW.) WARB AND BRYOPHYLLUM PINNATUM (LAM) OKEN

Olawale H. Oladimeji, Ngozi O. Onu

Abstract


In the present study a semi-pure residue each from Pycnanthus angolensis (Welw.) Warb and Bryophyllum pinnatum (Lam) for the presence of biologically active compound(s) were investigated. This exercise led to two compounds whose identities have been established to be 1,6-dihydro-2-methyl-4-hydroxy-6-oxo-3-pyridine carboxylic acid ethyl ester (1,6-dihydro-2-methyl-4-hydroxy-6-oxo-3-nicotinic acid ethyl ester) (5-ethoxycarb, NG5-a) and 1-ethoxy-2-hydroxy-4-prophenylguaethol (vanitrope, KF-1a), respectively using MS and IR spectral techniques. NG-5a was proved to be bacteriostatic against Escherichia coli but recorded no activity against Staphylococcus aureus and Candida albicans. KF-1a recorded only minimal activity against S. aureus but demonstrated no activities against E. coli or C. albicans.


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DOI: http://dx.doi.org/10.17628/ecb.0.0.190-193

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