Design, Synthesis and Biological Evaluation of Schiff Bases and Their Co(II), Cu(II), Ni(II) Chelates from Derivative Containing Indole Moiety Bearing-Triazole

Rehab K. Al-Shemary


The important bicyclic ring system such as Indole contains of pyrrole ring fused with the benzene ring. Although indole moiety is very small but is fascinated by scientists because of the diverse biological activities by not only indole but its various substituted derivatives as well. In the present study, some novel indole derivatives like methyl- 2-(1H-indole-3-yl)-ethanoate derivatives (D1 to D5) were synthesized according to the scheme. Then synthesis three Schiff bases by conduction between Indole derivative 3-[(5-hydrazinyl-4-phenyl-1, 2, 4-triazol-3-yl)-methyl]- 1H-indole D5 and deferent substituted benzaldehyde compounds 2-Hydroxy benzaldehyde or 2-methoxy benzaldehyde or 2-Hydroxy-3-methoxybenzaldehyde The synthesized indole derivatives and novel Schiff bases have been characterized by using elemental analysis, FT-IR, 1HNMR spectroscopy and further supported by Mass spectroscopy for D4 compound. Co(II), Cu(II) and Ni(II) complexes were prepared from reaction these ions with Schiff bases  (D 6-D8). The Ligands and their complexes were characterized by spectral methods  [FT- IR , UV – Vis , Atomic absorption , 1HNMR ] in addition to molar conductivity, Magnetic moment effect, Microanalysis (C.H.N)  and melting point . Then all the compounds exhibited moderate to significant anti-bacteria and anti-fungi activities were screened the bacteria as E. coli, S. aurous, B. subtitles, P. aeruginosin,   and fungi were as A. niger, A. flavours, R. stolonifera and C. Albicans.

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