Synthesis of Tetrahydrobenzo[B]Pyran Derivatives Using Thiamine Hydrochloride (VB1) : A Green Catalyst

Devidas S. Bhagat, Jagadish L. Wawre, Ashok R. Yadav, Pintu G. Pathare, Laszlo Kotai, Rajendra P. Pawar


An environmentally safer synthesis of 2-amino-tetrahydro-4H-chromenes derivatives using vitamin B1 was achieved by one pot synthesis. In this reaction condensation of various aromatic aldehydes, malononitrile and dimedone at room temperature without addition of any other catalyst has been done. The desired products can be separated directly from the reaction mixture with high purity. This synthetic method is inexpensive, efficient, as well as eco-friendly.

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