ANGIOTENSIN-CONVERTING ENZYME AND ITS GENE POLYMORPHISM (I/D) IN ESSENTIAL ARTERIAL HYPERTENSION

Mohamed A. Taher, Ahmed M. Boghdady, Eman A. Sabet, Usama A. Arafa, Ahmed I. Abd Elneam

Abstract


The polymorphisms of ACE gene has been investigated using polymerase chain reaction for detection of ACE I/D genotype  frequency in hypertensive cases in sector of Egyptian population. Serum ACE is significant higher in hypertensive group than normotensive one (27.5± 4.4 and 21.3± 5.4 ng/m respectively. Means SBP (systolic blood pressure), DBP (diastolic blood pressure) and urinary protein excretion in DD genotype were 181±17 mmHg, 112±19mmHg, 38±4.8mg/dl and 141.5± 36.8mg/24h respectively but, in II genotype were 142± 10 mmHg, 99± 13 mmHg, 43.5±4 mg/dl and 116.4± 36 mg/24h respectively. In hypertensive patients, serum ACE levels in DD, ID and II genotypes were 36.2± 5.7, 22.1± 3.7 and 24.5± 4.9 respectively. D/D ACE gene polymorphism plays a role in the development of target organ damage in sever essential hypertension and might have a prognostic value. It can be considered as one of risk factor of hypertension.  


Full Text:

pdf


DOI: http://dx.doi.org/10.17628/ecb.2015.4.531-534

Refbacks

  • There are currently no refbacks.


 

*********************** European Chemical Bulletin *******************