Catalysis by triflic acid: Synthesis of the indolylquinones as potential antitumor agent.

Feyriel Dridi, Didier Villemin, Nathalie Bar Bar, Messaoud Hachemi, Remi Legay

Abstract


Trifluoromethanesulfonic acid catalyzes efficiently the conjugate addition of indoles to p-benzoquinones under mild conditions affording the corresponding indolylquinones in high yields with high selectivity.

In particular the poorly reactive menadione underwent reaction with indoles under similar conditions to give 3-indolylnaphthoquinones.


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DOI: http://dx.doi.org/10.17628/ecb.2015.4.543-547

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