Determination of Cancer Antigen CA15-3 and Alpha feto protein (AFP) Levels as Tumor Marker in Patients with Breast and Prostate Cancer.

Rana Kareem Mohammed, Salah Mohammed Fizea


The objective of the present study is to evaluate the values of cancer antigen (CA15-3) and alpha feto protein (AFP) in patients with breast and prostate cancer. Since both studied parameters are expressed either during malignancy or benign in many tissues.

   The study conducted on seventy one subjects grouped as 36 patients with breast cancer G1, 10 patients with prostate cancer G2, and 25 normal healthy controls with range of (40-55) years old. The patients were admitted to Al khadmiya Teaching Hospital for treatment.

    Serum CA15-3 and AFP were measured by enzyme linked immunosorbent assay (ELISA) using special kits.

    Statistical analyses were performed by using Statistical Package for Social Sciences (SPSS) version 19.0 and Microsoft Excel 2010 for data processing and graph construction. Statistical significant difference was (p≤0.05) .and highly significant difference was (p≤0.001).

  The results revealed the values for CA 15-3 in serum of G1 showed a highly significant increase compared to normal healthy subjects, but CA15-3 in serum of G2 was compatible with control. The results showed the value of serum AFP in G1 (was not significant different) when compared to control, while a highly significant difference in G2 was noticed when compared to healthy subjects.

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