A NEW METHOD FOR THE SYNTHESIS OF NANOPARTICLES FOR BIOMEDICAL APPLICATIONS

Sh. Kekutia, L. Saneblidze, V. Mikelashvili, J. Markhulia, R. Tatarashvili, D. Daraselia, D. Japaridze

Abstract


New chemical synthesis methods for producing nano-sized iron oxides particles and producing biocompatible polymer coated nanoparticles in the solution has been investigated. A new particle processing device for making high performance nanomaterials as well as their applications in medicine has been developed by applying electrohydraulic technique for nanohomoganization. Biomedical application requires the biocompatible super paramagnetic iron oxide nanoparticles (SPIONs), which are stable and well dispersed in water at physiological pH or in physiological salinity. In order to obtain biocompatible SPIONs, particles of 10-15 nm size have been synthesized and these SPIONs have been coated with ascorbic acid. Vibrating Sample Magnetometer studies (VSM) were carried out to study the effect of phase transformations on the magnetic properties of the nanoparticles. The samples were analyzed by VSM at room temperatures to find the saturation magnetization. The ascorbic acid coated iron oxide nanoparticles were found to be well dispersed in water as they have a hydrophilic outer surface containing hydroxyl and amine groups. This hydrophilic outer surface is likely to enhance their bioactivity. Therefore they may become a very good drug carrier for biomedical applications.

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DOI: http://dx.doi.org/10.17628/ecb.2015.4.33-36

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