An overview on synthetic methods of iso-propyl chloroacetate

Liu Shu, You Hongjun


Nowadays a lot of synthetic methods of isopropyl chloroacetate using different catalysts such as sulfonic acids (p-toluene-sulfonic acid and  amino-sulfonic acid), inorganic metal salts of organic sulfonates (Ce(CH3SO3)3∙H2O, Ca(CH3SO3)2∙2H2O, Al(CH3SO3)3∙4H2O, Zn(CH3SO3)2∙4H2O, La(CH3SO3)3∙4H2O, Cu(CH3SO3)2∙4H2O, Zn(p-CH3C6H4SO3)2∙5H2O, Zn(C6H5SO3)2∙6H2O, CH3(CH2)11SO3Na and (CH3(CH2)11SO3)3Fe), ionic liquids ([(CH2)4SO3HPy]HSO4 and [C1imCH2COOH]HSO4), inorganic salts (Ce(SO4)3∙4H2O, NaHSO4, KHSO4,  [Fe2(OH)n(SO4)3-n/2]m, CPVC-FeCl3, NH4Fe(SO4) ∙12H2O,  PVC-FeCl3,  FeCl3∙6H2O and SnCl4), PCl3, heteropolyacids (H3PO40W12.xH2O and  TiSiW12O40/TiO2), solid superacids (SO42-- Fe2O3, SO42-/TiO2-La3+, SO42-/TiO2, SO42-/TiO2-Sm3+, SO42NiO, SO42-/TiO2-Nd3+, SO42-- Al2O3, SO42-/TiO2-Gd3+ and SO42-/TiO2-Ce3+) and inorganic salts of organic acids (Nd(CF3COO)3) have been reviewed in the present paper. The yields of isopropyl chloroacetate are improved by the addition of above catalysts. These methods are having the advantages of simple process and low investment costs.

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