D-arabino-hex-1-enitol from the inactive fraction of Acalypha wilkesiana var. lace-acalypha (Muell &Arg.)
Different herbal preparations of Acalypha.wilkesiana var. lace-acalypha (Muell & Arg.) are employed in traditional medicine for the treatment and management of disease conditions such as wounds, tumors, hypertension, inflammations, skin infections, gastroenteritis amongst many others. Ethyl 3, 4, 5-trihydroxybenzoate (ethyl gallate) and 1, 2, 3-benzenetriol (pyrogallol) have previously been isolated from the active fractions of this plant. However, this present study was done to isolate compound(s) from one of the inactive fractions. Hence, a short silica-gel column chromatography of the inactive fraction (5A) furnished a compound designated as 3 [Rf 0.15; [n]20D 1.0300 ]. The structure of 3 has been established to be D-arabino-hex-1-enitol-1, 5-anhydro-2-deoxy (1, 5-anhydro-2-deoxy-D-enopyranose-arabino-hex-1-enitol) by a combination of 1H NMR, 13C NMR, MS and IR spectral techniques. Compound 3 recorded no antibacterial activity against B. subtilis, S. aureus and Ps. aeriginosa. However, it demonstrated very weak antibacterial activities against E. coli and S. typhi.which were slightly better than the activity furnished by 5A. Furthermore, it was observed that 3 was inactive against C. albicans. Surprisingly, the crude extract and butanol fraction generally demonstrated comparably stronger antimicrobial activities than 3 implying that the purification of the crude extract did not improve the activity demonstrated by 3.
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