EFFECT OF PROTEINOUS AND NON-PROTEINOUS FRACTIONS ISOLATED FROM PHASEOLUS VULGARIS AND VIGNA SINENSIS FRUITS ON DIABETIC MICE

Nahida Saieed Hamoodi Al-Chalabi, Shehab Ahmed Yousif Al-Bajari

Abstract


This study is concerned with the preparation of cold and boiled aqueous extracts from the fruits of both phaseolus vulgaris and Vigna sinensis plants, then isolating the proteinous compounds from these extracts by cold acetone precipitation method and therefore to separate the non-proteinous fraction. The work included the study of the effect of intraperitoneal administration of cold and boiled aqueous extracts, proteinous acetone precipitates, and non- proteinous materials isolated from these extracts on certain blood biochemical constituents (parameters) using a dose of 77 mg/Kg of body weight in normal and alloxan-induced diabetic mice. The results had been compared with those injected with insulin. The results showed that the boiled crude aqueous extract of Vigna sinensis plant and its isolated proteinous precipitate has a significant decrease effects for the level of the glucose and total lipids in the blood. On the other hand, the non-proteinous substance of cold aqueous extract of Phaseolus vulgaris fruit has a decrease effect for the level of glucose, cholesterol and total lipids in the blood serum of alloxan- induced diabetic mice, therefore may be used in the treatment of diabetes mellitus after make sure there is no side effects as well as we concluded that these materials mentioned above may be used in the treatment of diabetes mellitus .


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DOI: http://dx.doi.org/10.17628/ecb.2014.3.658-663

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