DESCRIPTORS FOR ARTEMISININ AND ITS DERIVATIVES; ESTIMATION OF PHYSICOCHEMICAL AND BIOCHEMICAL DATA

Michael H. Abraham, William E. Acree

Abstract


Properties, or descriptors, of artemisinin and some of its derivatives have been obtained from known solubilities and water-octanol partition coefficients. These descriptors can then be combined with already known equations to yield water-solvent partition coefficients and solubilities in a very large number of solvents, so that it is now possible to select suitable solvents for purification, etc. Combination of the descriptors with known equations for blood-tissue partitions enables partition coefficients to be estimated for partitions from blood to brain, muscle, liver, lung, kidney, heart, skin and fat. Where data on blood-tissue partitions exist, there is agreement with experiment.


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DOI: http://dx.doi.org/10.17628/ecb.2013.2.1027-1037

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