E-ISSN 2063-5346
 

Research Article 


DESIGN AND CHARACTERIZATION OF NEBIVOLOL SOLID DISPERSION FAST DISINTEGARTING TABLETS

Madhuri Latha. Thadanki, Dr. Maddi Ramaiah.

Abstract
Objective: This study was mainly designed to solve the drawback of conventional Nebivolol solid dosage form, low
bioavailability and limited clinical efficacy, by preparing Solid dispersion. Methods: Nebivolol solid dispersionwas developed by
kneading method to modify the release and enhance solubility of the drug. The physical state of the dispersed Nebivolol in the
polymer matrix was characterized by differential scanning calorimetry, powder X-ray diffraction, scanning electron microscopy,
Fourier-transform infrared spectroscopy, super saturation solubility testing and dissolution studies. Optimized Nebivolol solid
dispersions were formulated into tablets by direct compression method. Results: Compared with pure drug and physical mixture,
the dissolution of Nebivolol - Solid dispersion was enhanced dramatically. Optimized Nebivolol solid dispersions tablet showed
faster drug release in comparison to marketed tablet. Optimized formulation follows Higuchi’s equation and the release mechanism
is super case II transport. Conclusion: The present study conclusively indicated that the use of solid dispersion method by using
water soluble carriers improved the solubility of poorly water soluble drug.

Key words: Solid dispersion, Nebivolol, Tablets, Optimization, Solubility enhancement.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Madhuri Latha. Thadanki
Articles by Dr. Maddi Ramaiah
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Madhuri Latha. Thadanki, Dr. Maddi Ramaiah. DESIGN AND CHARACTERIZATION OF NEBIVOLOL SOLID DISPERSION FAST DISINTEGARTING TABLETS. ECB. 2022; 11(4): 70-80. doi: 10.31838/ecb/2022.11.04.011


Web Style

Madhuri Latha. Thadanki, Dr. Maddi Ramaiah. DESIGN AND CHARACTERIZATION OF NEBIVOLOL SOLID DISPERSION FAST DISINTEGARTING TABLETS. https://www.eurchembull.com/?mno=96569 [Access: August 09, 2022]. doi: 10.31838/ecb/2022.11.04.011


AMA (American Medical Association) Style

Madhuri Latha. Thadanki, Dr. Maddi Ramaiah. DESIGN AND CHARACTERIZATION OF NEBIVOLOL SOLID DISPERSION FAST DISINTEGARTING TABLETS. ECB. 2022; 11(4): 70-80. doi: 10.31838/ecb/2022.11.04.011



Vancouver/ICMJE Style

Madhuri Latha. Thadanki, Dr. Maddi Ramaiah. DESIGN AND CHARACTERIZATION OF NEBIVOLOL SOLID DISPERSION FAST DISINTEGARTING TABLETS. ECB. (2022), [cited August 09, 2022]; 11(4): 70-80. doi: 10.31838/ecb/2022.11.04.011



Harvard Style

Madhuri Latha. Thadanki, Dr. Maddi Ramaiah (2022) DESIGN AND CHARACTERIZATION OF NEBIVOLOL SOLID DISPERSION FAST DISINTEGARTING TABLETS. ECB, 11 (4), 70-80. doi: 10.31838/ecb/2022.11.04.011



Turabian Style

Madhuri Latha. Thadanki, Dr. Maddi Ramaiah. 2022. DESIGN AND CHARACTERIZATION OF NEBIVOLOL SOLID DISPERSION FAST DISINTEGARTING TABLETS. European Chemical Bulletin, 11 (4), 70-80. doi: 10.31838/ecb/2022.11.04.011



Chicago Style

Madhuri Latha. Thadanki, Dr. Maddi Ramaiah. "DESIGN AND CHARACTERIZATION OF NEBIVOLOL SOLID DISPERSION FAST DISINTEGARTING TABLETS." European Chemical Bulletin 11 (2022), 70-80. doi: 10.31838/ecb/2022.11.04.011



MLA (The Modern Language Association) Style

Madhuri Latha. Thadanki, Dr. Maddi Ramaiah. "DESIGN AND CHARACTERIZATION OF NEBIVOLOL SOLID DISPERSION FAST DISINTEGARTING TABLETS." European Chemical Bulletin 11.4 (2022), 70-80. Print. doi: 10.31838/ecb/2022.11.04.011



APA (American Psychological Association) Style

Madhuri Latha. Thadanki, Dr. Maddi Ramaiah (2022) DESIGN AND CHARACTERIZATION OF NEBIVOLOL SOLID DISPERSION FAST DISINTEGARTING TABLETS. European Chemical Bulletin, 11 (4), 70-80. doi: 10.31838/ecb/2022.11.04.011